Cameron County is a county in the Commonwealth of Pennsylvania. As of the 2020 census, the population was 4,547, making it Pennsylvania's least populous county. Its county seat is Emporium. The county was created on March 29, 1860, from parts of Clinton, Elk, McKean, and Potter Counties. It is named for Senator Simon Cameron. The county is part of the No…Cameron County is a county in the Commonwealth of Pennsylvania. As of the 2020 census, the population was 4,547, making it Pennsylvania's least populous county. Its county seat is Emporium. The county was created on March 29, 1860, from parts of Clinton, Elk, McKean, and Potter Counties. It is named for Senator Simon Cameron. The county is part of the North Central Pennsylvania region of the state.