Centralia is a city in Clinton, Jefferson, Marion, and Washington counties in the U.S. state of Illinois with the largest portion in Marion County. T…Centralia is a city in Clinton, Jefferson, Marion, and Washington counties in the U.S. state of Illinois with the largest portion in Marion County. The city is the largest in three counties, Clinton, Marion, and Washington, but it is not a county seat for any of them. The population was 12,182 as of the 2020 census, down from 13,032 in 2010.