Herbert returns to the Bene Gesserit sisterhood throughout the original Dune books, where they mostly serve as antagonists, who struggle with Paul Atreides and his family for control over the Empire and Arrakis, the home of the superdrug Spice (or melange).

Dune: Prophecy is a strong start for the sci-fi franchise's new series, which tracks the origin of the Bene Gesserit decades after a major war.