Among the explanations offered for tau’s detrimental effects on neurons in Alzheimer disease is that elevations in tau levels, and/or changes in its cellular distribution, disrupt microtubule function ...

The mutant protein that causes Huntington disease blocks axonal traffic by putting the molecular equivalent of the wheel-locking “boot” on motor proteins, according to a paper published online June 14 ...

Inhibition of fast axonal transport might be an early event in the molecular pathology of a number of neurodegenerative disorders.Various studies have indicated that the mutant form of the huntingtin ...

Many cellular processes depend on the trafficking of organelles, vesicles and macromolecules by cytoskeletal motors. Neurons are particularly dependent on long-range cytoskeletal transport because of ...

A physical dimension of a cell is seldom its Achilles' heel. Yet for the neurons that are affected in most kinds of peripheral neuropathy, it is the length of their axons that best accounts for their ...

Neurons, specialized cells that transmit information across the nervous system, communicate with each other via projections known as axons. These microscopic, cable-like structures are also used to ...

(Medical Xpress)—Neurons have developed elaborate mechanisms for transporting critical components, like transmitter-laden vesicles, down their axons to the synaptic terminations. An axon in a blue ...

Alzheimer's dementia is caused by accumulation of amyloid-β protein in neurons, formed from proteolytisis of amyloid precursor protein (APP), but the normal role of APP in the brain remains unclear.

Axonal regeneration in the adult central nervous system is extremely limited after injury. As a consequence, there is typically little functional recovery after spinal cord injury, traumatic brain ...

Seeking students to contribute to research exploring motor-disease protein complexes and their role in intracellular transport, as they relate to disease initiation and the aging process, and the ...