T cell development is a tightly regulated process that transforms immature thymocytes into mature T cells with distinct functionalities. In the thymus, precursor cells undergo a series of selection ...

Stem cell-derived endothelial cell differentiation represents a rapidly advancing field that leverages the plasticity of pluripotent cells to generate functional vascular components. Central to the ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

The 200 different types of cells in the body all start with the same DNA genome. To differentiate into families of bone cells, muscle cells, blood cells, neurons and the rest, differing gene programs ...

Single-molecule imaging shows that three CBX2 protein molecules can seed Polycomb condensates that silence genes in stem cells. The discovery reveals how rare proteins organize genome regulation and ...

The sugar glucose, which is the main source of energy in almost every living cell, has been revealed in a Stanford Medicine study to also be a master regulator of tissue differentiation - the process ...

MIAMI, FLORIDA (AUG. 7, 2025) – Researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, have documented their use of a new RNA sequencing ...

The cell and gene therapy industry has achieved breakthroughs once thought impossible, translating novel concepts into real therapeutic options for patients. The FDA has now approved 43 cell and gene ...

Glucose is life's main energy source. But a new study reveals a surprising role as a master manipulator of tissue maturation, hinting at its importance in diabetes and cancer. The sugar glucose, which ...

The International Society for Stem Cell Research (ISSCR) is pleased to announce that Alexander Meissner, Director at the Max Planck Institute for Molecular Genetics, Germany, has been named the ...