Binding of a ligand to the native three-dimensional configuration of a protein increases protein stability, with a corresponding increase in the protein’s melting temperature. This indirect ...
CETSA Is Now Being Used Routinely to Demonstrate Small Molecule’s Engagement of a Specific Target in the Cell The cellular thermal shift assay (CETSA) was first described approximately 2 years ago by ...
The cellular thermal shift assay (CETSA) is a powerful tool for confirming target engagement and deconvoluting mode of action in living cells. The principle behind CETSA is that a ligand – target ...
AstraZeneca has teamed up with Pelago Bioscience to examine how drug candidates interact with protein targets. The collaboration will apply Pelago’s cellular assay technology to the screening and ...
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