Cell-based models of the human cortex transplanted into mice produce neurons that are inaccessible in vitro, and could enable scientists to link brain injury to behaviour.

A new collection of studies using live human cortical tissue shows that human neurons and circuits follow distinct structural ...

A Japanese research team has successfully reproduced the human neural circuit in vitro using multi-region miniature organs known as assembloids, which are derived from induced pluripotent stem (iPS) ...

Over a decade ago, scientists redefined how to study organ development by generating seemingly unremarkable clumps of cells. They dubbed them organoids: organ-like microstructures produced using stem ...

A Nature Neuroscience commentary highlights new evidence that genetic variants within Alu transposable elements help shape ...

"Organoids offer a means to connect genetic and environmental alterations relevant to neuropsychiatric disorders with specific early cortical patterning events." A new model for cortex development ...

The outer regions of the brain, the cortex, have specific layers of different cells—neurons—that are similarly ordered among all mammals, from tiny mouse brains to huge elephant brains. However, the ...

Glutamine synthetase(GS) acts as a key regular of postnatal brain development, integrating metabolic control via the mTOR pathway to coordinate cell-specific gene expression, protein synthesis,and ...

Much of what makes us human can be traced to the cerebral cortex, a wrinkled sheet of gray tissue about an eighth of an inch deep that forms the outermost layer of the brain. It is the source of our ...

Perhaps our most defining characteristic as a species, the six-layered human cortex, hosts billions of neural connections that bestow Homo sapiens with higher-order thinking. But how does this ...