DNA replication and repair mechanisms constitute the foundation of genomic integrity, ensuring that genetic information is faithfully duplicated and maintained across cell generations. Replication ...

The ATR–ATRIP kinase complex safeguards genome integrity by coordinating cellular responses to DNA damage and replication stress. Two recent cryo-EM studies resolve the structural basis of ATR–ATRIP ...

DNA can be more than just a double helix. When four strands are folded into a compact bundle, they form a G-quadruplex (G4).

The Okazaki Fragments That Solved the Mystery of DNA Replication1. The Mystery That Could Not Be Solved by the Discovery of ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

In the middle of the 20th century, accumulating data suggested that DNA carries life’s genetic information. Biochemists around the world raced to determine its structure. The competition led to some ...

One of the most important milestones in modern science, does April 25 also mark the date of an intellectual heist? As has been well-documented, a third person contributed to the discovery — the ...

Seventy years ago, two male scientists, Francis Crick and James Watson, proclaimed they had discovered the secret of life: the structure of DNA. Since then, history has acknowledged how Rosalind ...