Mutations in LXRα lead to liver cholesterol buildup, hepatitis, and fibrosis in individuals on a Western diet, highlighting the receptor's role in maintaining liver health. Study: Damaging mutations ...

Gifu University scientists have uncovered how a brain-specific enzyme reshapes protein-linked sugar chains to facilitate the formation of complex glycans essential for normal brain function. These ...

Membrane receptors and transporters translate extracellular cues into cellular responses by harnessing conformational changes, ion flux or enzymatic activity. Fast-acting ligand-gated ion channels ...

Researchers from the International Institute of Molecular and Cell Biology in Warsaw (IIMCB) say they have created the first systematic catalog of the substrate receptors of cullin–RING ligases and ...

Life has evolved over billions of years, adapting to the changing environment. Similarly, enzymes—proteins that speed up biochemical reactions (catalysis) in cells—have adapted to the habitats of ...

How do related proteins develop different functions? This is the question investigated by a research team involving Kiel University, DESY and the Center for Structural Systems Biology (CSSB). Led by ...