A seminal paper by Miller and Brody [1] clearly laid the general framework on why we should abandon the term "clinical equipoise" in research. Their paper argued that the concept of equipoise (also ...

Clinical equipoise, or uncertainty about which treatment is best for a patient, is widely viewed as essential for an ethical RCT. The authors argue that clinical trials that violate equipoise are ...

RCTs incorporate several methodological characteristics intended to maximize the validity of conclusions about the efficacy and safety of the intervention under study. 1 First, they employ a ...

While his focus was on balancing personal freedom versus state power, 18th century political theorist John Locke’s following thought could arguably be applied to current pharmaceutical regulators’ ...

For more than a decade, the U.S. Preventive Services Task Force (USPSTF) [23] has published a ranking of clinical evidence. [24] The rankings, however, are based on what clinical investigators have ...