Expansion microscopy (ExM) is an attractive route to nanoscale imaging for labs without conventional super-resolution microscopes. It involves linking fluorescent markers through a gel infused into ...

A classical way to image nanoscale structures in cells is with high-powered, expensive super-resolution microscopes. As an alternative, MIT researchers have developed a way to expand tissue before ...

A classical way to image nanoscale structures in cells is with high-powered, expensive super-resolution microscopes. As an alternative, MIT researchers have developed a single-step technique for ...

Nearly 150 years ago, scientists began to imagine how information might flow through the brain based on the shapes of neurons they had seen under the microscopes of the time. With today's imaging ...

A collection of protocols covering a variety of methods to achieve super resolution in microscopy to include structured illumination, single-molecule fluorescence and localization-based approaches.

In biology, seeing can lead to understanding, and researchers in Professor Edward Boyden's lab at the McGovern Institute for Brain Research are committed to bringing life into sharper focus. With a ...

When Benjamin Liffner, a parasite biologist at Adelaide University, learned how to perform expansion microscopy as a postdoctoral researcher at Indiana University, he immediately appreciated the ...

Expansion microscopy enhances conventional imaging by physically enlarging samples within a hydrogel matrix, surpassing diffraction limits. In this Primer, Vo et al. detail typical expansion ...