Signal transduction is a key mechanism that brings about several physiological responses in a cell. Aberrant signaling can result due to gene mutations or regulatory protein overexpression. It is ...

G protein-coupled receptors (GPCRs) are essential for cell signal transduction and comprise the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple ...

GPCRs are a large family of receptors found in the cell membrane of almost all living organisms. They are responsible for cell communication, acting like sentinels between cells, ready to recognise ...

Researchers at University of California San Diego have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse ...

Researchers at University of California San Diego have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse ...

G protein–coupled receptors (GPCRs) initiate signaling cascades while ensconced in the cell membrane. At least, that’s where GPCRs are usually found. But some GPCRs ride endosomes into the cell’s ...

Activating the GPR133 receptor with a small molecule can rebuild bone from within, offering a new direction for osteoporosis ...