Brock Purdy and the San Francisco 49ers took on Aaron Rodgers and the New York Jets on Monday Night Football in their season opener at Levi’s Stadium as they seek to return to the Super Bowl.

As of Sept. 16, the San Francisco 49ers' odds of winning the Super Bowl (+600) make them second-best in the NFL. The 49ers picked up a 23-17 loss to the Minnesota Vikings in their most recent outing.

Looking at Sunday’s San Francisco 49ers at LA Rams Week 3 NFL odds, lines and trends. Here’s what you need to know.

The San Francisco 49ers and Los Angeles Rams play on Sunday, Sept. 22, at SoFi Stadium in a game on the NFL Week 3 schedule. Which team will win the Week 3 NFL game? Check out these NFL Week 3 ...

Take a look at some of the San Francisco 49ers best plays versus NFC West opponents of all time. San Francisco 49ers linebacker Fred Warner punched the football out of the grasp of Minnesota ...

Take a look at some of the San Francisco 49ers best plays versus NFC West opponents of all time. San Francisco 49ers linebacker Fred Warner punched the football out of the grasp of Minnesota ...

Sam Darnold shines in Vikings' home debut, leading team to victory over 49ers with impressive passing. Vikings' defense has ...

In Week 2 of the 2024 season, Jordan Mason and the San Francisco 49ers will match up with the Minnesota Vikings at 1:00 PM ET on Sunday. If you're trying to find Mason's stats, here's everything ...

San Francisco 49ers fans excited for beginning of new season 03:39 San Francisco coach Kyle Shanahan said All-Pro running back Christian McCaffrey could have played in the 49ers' opener if it had ...

San Francisco 49ers wide receiver Deebo Samuel will be sidelined the next few weeks. On Monday, 49ers coach Kyle Shanahan told reporters that Samuel will miss "a couple weeks" due to a calf strain ...

The 49ers managed to avoid punishment for the apparent concealment of running back Christian McCaffrey’s true injury status on Monday, in large part because the NFL doesn’t need to be telling the ...