Alpha-actinin can cross-link actin filaments and anchor them to the Z-disk in sarcomeres. Sarcomeres are a structural unit of myofibril in striated muscle. The FATZ (filamin, α-actinin- and telethonin ...

A non-monotonic force–velocity relationship in cardiac sarcomeres causes dynamic instability, leading to stochastic heterogeneity in contracting cardiomyocytes, which can have a protective function.

An international team, led by Stefan Raunser, Director at the Max Planck Institute of Molecular Physiology in Dortmund, in collaboration with Mathias Gautel at the King's College in London, has ...

Thick filament structure in the relaxed cardiac sarcomere. The upper image shows a tomographic slice of a cardiac sarcomere. Thin filaments are marked with a green and thick filaments with a purple ...

Scientists have produced the first high-resolution 3D image of the sarcomere, the basic contractile unit of skeletal and heart muscle cells, using electron cryo-tomography (cryo-ET). The international ...