Giants vs. Cowboys odds, prediction, time, spread: Thursday Night Football picks from NFL model on 42-22-run
Kickoff from MetLife Stadium in East Rutherford, N.J., is set for 8:15 p.m. ET. The Cowboys are 5.5-point favorites in the latest Giants vs. Cowboys odds, while the over/under for total points scored is 45.5. Before making any Cowboys vs. Giants picks, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.
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