A defining duo of the first Donald Trump administration is back.

Sen. Lisa Murkowski announced Thursday she will vote against confirming Pete Hegseth to lead Pentagon, becoming the first Republican to oppose one of President Donald Trump’s cabinet picks.The Alaska Republican’s decision comes ahead of a crucial test vote to advance Hegseth’s nomination toward confirmation.

The Senate voted largely along party lines Thursday to advance Pete Hegseth, President Trump’s nominee to serve as secretary of Defense, brushing aside a litany of misconduct allegations and the objections of Democrats who argued he is unqualified for the job.

Lisa Murkowski of Alaska and Sen ... is prepared to be the next secretary of defense,” the chairman, Sen. Roger Wicker, R-Miss., said in a statement on the eve of voting.

Lisa Murkowski announced Thursday that she ... is prepared to be the next secretary of defense,” the chairman, Sen. Roger Wicker, R-Miss., said in a statement on the eve of the test vote.

Vice President J.D. Vance cast a tie-breaking vote as Hegseth overcame allegations of sexual assault, public drunkenness and questions of financial mismanagement to win Senate approval.

The Senate voted to confirm President Donald Trump's nominee, Pete Hegseth, as defense secretary on Friday night after a high-tempered battle to sway lawmakers in his favor that was almost derailed by accusations about his behavior.

Pete Hegseth was sworn in to lead the Department of Defense on Saturday, after a narrow vote in the Senate.The vote on Friday night was initially

Three Republicans voted with every Democrat against Trump’s controversial pick to lead the Pentagon, forcing Vance to step in and put Hegseth over the top.

Pete Hegseth has vowed to bring his “warrior” ethos to the Pentagon. Democrats had assailed him as unfit for the job, and his confirmation came down to Vice President JD Vance serving as tiebreaker.

Donald Trump's pick for Defense Secretary, faced stiff criticism from Democrats and some Republicans—requiring a tie-breaking vote from JD Vance.

Vice President J.D. Vance cast the tie-breaking vote after Sens. McConnell, Murkowski and Collins voted against the Fox News host’s confirmation