As Colorado geared up for the 2025 season, however, Sanders revealed he'd been diagnosed earlier this year with an aggressive form of bladder cancer that required surgery, a treatment he and his medical team deemed successful, culminating in a July 28 press conference announcement that he is now cancer-free.

Colorado football coach Deion Sanders was diagnosed with an aggressive form of bladder cancer earlier this year.

Some bladder cancer patients opt for intravesical therapy, which means chemotherapy is administered directly into the bladder; others benefit from approaches like immune checkpoint inhibitors, or a combination of both. During the press conference, Sanders said he chose to have his tumor surgically removed, which is called a cystectomy.