The San Francisco 49ers lost star running back Christian McCaffrey in Week 13 during a brutal 35-10 blowout loss against the ...

Jenna Purdy, the wife of 49ers quarterback Brock Purdy, was in attendance at Levi's Stadium for "Monday Night Football." She ...

"49ers Talk" co-hosts Matt Maiocco and Jennifer Lee Chan discuss San Francisco 49ers wide receiver Rick Pearsall’s breakout game vs. the Detroit Lions on Monday night at Levi's Stadium.Pearsall has br ...

Fresh off the big win over the 49ers on Monday night and with little sleep, the Detroit coach got his special coffee and headed right back to work.

Amon-Ra St. Brown and the Detroit Lions will visit George Kittle and the San Francisco 49ers on Monday at 8:15 p.m. ET, in a ...

The Lions knocked off the 49ers on "Monday Night Football" but it was the Tennessee Volunteers fans that also had reason to ...

The Detroit Lions capped the first unbeaten road schedule in team history on Monday night in San Francisco. The Lions ...

While 49ers fans headed towards the stadium's exit after the game ended, Lions fans remained in their seats and even moved ...

Brock Purdy threw for a career-high 377 yards and three touchdowns as the San Francisco 49ers fell to the Detroit Lions 40-34 ...

The Detroit Lions fought hard to defeat the San Francisco 49ers, but behind that victory, Dan Campbell revealed he had to ...

Freedom Williams and Smooth Jammy from C+C Music Factory and MIMS join 1st & 10 to preview the Detroit Lions vs. San Francisco 49ers "Monday Night Football" contest and talk halftime performance and ...

The San Francisco 49ers gave the Detroit Lions all they could handle for much of their showdown at Levi's Stadium in Santa ...