How cells turn mechanical forces into biochemical signals

Cells constantly probe their environments, searching for physical cues that guide their behavior. And yet a cell's response ...

Scientists uncover how the intestine balances cell growth and maintenance

A new preclinical study from Weill Cornell Medicine found that the protein caspase-5 (CASP5), long thought to be a foot ...

Your liver is hiding a shifting cellular map, and diet can rapidly redraw its internal landscape

As we go about our day, the trillions of cells in our bodies run like well-oiled machines: continually sensing what's happening around them and making modifications to keep us humming along. Like ...
eLife

Multifaceted Functional Complexity of SARS-CoV-2 Helicase Nsp13 Underlies Its Integrated Motor and Remodeling Activities

This study characterizes several novel activities of SARS-CoV-2 helicase nsp13, providing valuable insights into potentially new functions of this essential RNA-processing enzyme in the virus life ...
eLife

mRNA Imprinting: transcription apparatus can remotely control cytoplasmic post-transcriptional mechanisms by dozens of proteins

In this valuable study, the authors develop new approaches to investigate mRNA imprinting, a phenomenon in which RNA-protein complexes form in the nucleus to influence the fate of transcripts in the ...
thorax.bmj

Determinants of declining lung function trajectories from childhood to adulthood after preterm birth

Background Preterm birth is associated with lifelong respiratory sequelae, yet our understanding of lung function ...

Nanobody repairs misfolded CFTR inside cells, boosting function in cystic fibrosis

A tiny antibody component could fundamentally transform the treatment of cystic fibrosis: For the first time, researchers ...