Trough levels should be obtained within 30 minutes before the next scheduled dose. Weekly vancomycin levels should be obtained for long-term vancomycin use with stable renal function.

In adults with normal renal function, the half-life of vancomycin is 6 to 12 hours. 2 If steady state occurs within five half-lives (that is, in 30 to 60 hours), a vancomycin trough before the fourth dose is …

Nov 18, 2019 · Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for vancomycin …

Feb 22, 2023 · Do not restart vancomycin until the random/trough level is estimated or confirmed to be at/near 10-20 mg/dl. Allow sufficient time for drug clearance before restarting next dose.

Sep 21, 2025 · For most infections, the normal vancomycin trough concentration should be 15-20 μg/mL, particularly for serious infections such as bacteremia, infective endocarditis, osteomyelitis, …

A concise guide to interpreting vancomycin trough levels, timing the draw, and adjusting the dose safely especially in renal dysfunction.

Vancomycin serum trough concentrations of 15–20 mg/L are recommended to improve penetration, increase the probability of obtaining optimal target serum concentrations and improve clinical outcomes.

Selecting and interpreting trough levels: Always interpret trough level in context of timing of the preceding dose, particularly if the level appears to be much higher or lower than expected Trough for …

Aug 19, 2025 · There is no single “normal” vancomycin trough level that applies to all patients. Instead, healthcare providers aim for specific target ranges that depend on the type and severity of the …

Improving renal function increases clearance of vancomycin and can lead to lower trough levels. Refer to renal function table and re-calculate vancomycin dose as appropriate. Deteriorating renal function …