In biology, reprogramming refers to erasure and remodeling of epigenetic marks, such as DNA methylation, during mammalian development or in cell culture. [1] Such control is also often …

Apr 9, 2025 · This review summarizes the recent advances in cell reprogramming mediated by transcription factors or chemical molecules, followed by elaborating on the important roles of …

6 days ago · Morris discusses how single-cell genomics and computational tools expose failure points in reprogramming and guide protocols that improve the fidelity, maturity and purity of …

In 2006, scientists led by Shinya Yamanaka at Kyoto University in Japan pioneered a new technology, known as induced pluripotent stem cells, or iPSC for short. This breakthrough …

2 days ago · Precision Reprogramming: How AI Tricks Cancer’s Toughest Cells Tricking cancer cells into self-destructing could reduce risk of recurrence and death in colon cancer by 50%. …

In addition to problems of safety, reprogramming thus far been a very inefficient process – only about one in every 1,000 mature cells is successfully reprogrammed.

Aug 24, 2023 · Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate and generate desired cell types including pluripotent stem cells for applications in …

Mar 27, 2025 · This review summarizes the recent advances in cell reprogramming mediated by transcription factors or chemical molecules, followed by elaborating on the important roles of …

This Review discusses the evolution of direct reprogramming from a transcription factor-based method to a small-molecule-driven approach, the recent progress in enhancing reprogrammed …

Oct 9, 2025 · Cell reprogramming is the process of reverting mature, specialised cells into induced pluripotent stem cells. Reprogramming also refers to the erasure and re …