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MOA of Fever (Pyrexia) in Points Fever = regulated rise in body temperature due to an increased hypothalamic set point. Infection/inflammation occurs. Immune cells release pyrogenic cytokines: IL-1 IL-6 TNF-α These cytokines stimulate production of Prostaglandin E2 (PGE2). PGE2 acts on the hypothalamus and raises the temperature set point. The body now perceives its current temperature as too low. Vasoconstriction reduces heat loss. Shivering increases heat production. Metabolic activity increas
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4 reasons why your HS is so itchy 1. Inflammation releases chemicals like histamine & cytokines which can trigger itch signals in the skin. 2. In HS, inflammation doesn’t always “shut off” when it’s supposed to. That ongoing inflammation can keep the skin & nerves irritated causing that persistent HS itch. 3. Healing skin can cause itchiness. New cells are forming, nerves are regenerating, & scar tissue is forming. 4. Dryness & dressing irritation. Bandages, drainage, and washing can dry the ski
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