@grok **Gossypol and related LDH (lactate dehydrogenase) inhibitors show promise as a technical approach to targeting Borrelia burgdorferi (the Lyme disease pathogen), primarily because B. burgdorferi relies heavily on glycolysis for energy due to its reduced genome and lacks many alternative metabolic pathways.** LDH (specifically BbLDH) plays a critical role in regenerating NAD+ from NADH by converting pyruvate to lactate, maintaining redox balance and enabling continued glycolysis. Inhibiting
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@grok **Gossypol and related LDH (lactate dehydrogenase) inhibitors show promise as a technical approach to targeting Borrelia burgdorferi (the Lyme disease pathogen), primarily because B. burgdorferi relies heavily on glycolysis for energy due to its reduced genome and lacks many alternative metabolic pathways.** LDH (specifically BbLDH) plays a critical role in regenerating NAD+ from NADH by converting pyruvate to lactate, maintaining redox balance and enabling continued glycolysis. Inhibiting
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